ATG for cord blood transplant: yes or no?

(and poor outcome). Of interest, recent publications underscore the importance of the perturbed cell-cycle regulation machinery and demonstrate the sensitivity of DLBCL cell lines to targeted therapy by a pan CDK inhibitor. Further, the noncanonical TGF-b signaling (ie, the phosphorylation and activation of SMAD1/5 by TGF-b) appears to play a bigger role in controlling TGF-b signals than initially thought. Finally, targeting SMAD5 may at least partially explain the deficient generation of B cells in miR-155 KO mice. However, one should also clearly emphasize the limitations of this study, especially that patient samples were not analyzed. Thus, further experiments to demonstrate the relevance of these findings in humans, particularly whether miR-155 expression impacts RB function and E2F target gene expression, are warranted. Conflict-of-interest disclosure:The authors declare no competing financial interests. n